Plavix 75 mg film-coated tablets. Each film-coated tablet contains 75 mg of clopidogrel (as hydrogen sulphate). Excipients with known effect: Each film-coated tablet contains 3 mg of lactose and 3.3 mg of hydrogenated castor oil. DOSAGE AND ADMINISTRATION Acute Coronary Syndrome. In patients who need an antiplatelet effect within hours, initiate Plavix with a single 300 mg oral loading dose and then continue at 75 mg once daily. Over the past 20 years, fewer older adults suffered myocardial infarction and outcomes improved in the United States, likely thanks to national prevention efforts and improved care, researchers say. After six weeks, all subjects were tested again to measure the extent of their angina and exercise capacity. The investigators found that, while those who actually received stents seemed to have a bit more improvement than those who had the sham procedure, the difference between the two groups was not close to being statistically significant. Symptoms on Stopping: Any problems that appear on withdrawal or stopping including immediate rebound effects linked to the drug or illness, and prolonged reactions that endure after a drug has been stopped. Plavix Pharmacokinetics Absorption Bioavailability. Rapidly absorbed after oral administration; 1 ≥50% of an oral dose is absorbed. 1 Peak plasma concentrations of the active metabolite occur approximately 30–60 minutes following an oral dose. 1 Acute Coronary Syndrome (ACS) Plavix is indicated to reduce the rate of myocardial infarction (MI) and stroke in patients with non–ST-segment elevation ACS (unstable angina [UA]/non–ST-elevation myocardial infarction [NSTEMI]), including patients who are to be managed medically and those who are to be managed with coronary revascularization. Clopidogrel has a reduced effect on platelet function in patients who are homozygous for nonfunctional alleles of the CYP2C19 gene (i.e., poor metabolizers). Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease). Learn about side effects, drug interactions, dosages, warnings, and more. Page 2 of 5 3. Cardiovascular Disease -For patients with IHD, ischaemic cerebral infarction, TIA or peripheral artery disease who are unable to take aspirin due to contraindication, or known allergy (bronchospasm or rash).